منابع مشابه
Cytogenetics and molecular cytogenetics in diffuse large B-cell lymphoma (DLBCL).
BACKGROUND Diffuse large B-cell lymphoma (DLBCL) accounts for up to 40% of all non-Hodgkin's lymphomas diagnosed in the western hemisphere. Determination of the gene expression profile has confirmed the physiological heterogeneity of the disease and defined three molecular prognostic subgroups - germinal center B-cell-like (GCB), activated B-cell-like (ABC) and primary mediastinal B-cell lympho...
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trichrome (deep red) and Mallory phosphotungstic acid hematoxylin (deep blue). In addition, fibrin thrombi were observed in some sinuses. Rickettsiae were not found. In these two patients similar changes were also noted in liver biopsies: granulomas with fibrinoid ring and fibrin thrombi. Bone marrow changes in Q fever are not surprising because of the systemic distribution of the disease. Thes...
متن کاملFOXP1 molecular cytogenetics and protein expression analyses in primary cutaneous large B cell lymphoma, leg-type.
FOXP1 protein is expressed in normal activated B cells and overexpressed in a subset of diffuse large B-cell lymphomas, including primary cutaneous large B-cell lymphomas (PCLBCL), leg type. High expression of FOXP1 has been associated to an unfavourable prognosis with independent survival significance. However, little is known regarding the mechanisms underlying the overexpression of FOXP1 in ...
متن کاملCytogenetics of childhood T-cell leukemia.
The karyotypes of 57 cases of childhood T-cell acute lymphoblastic leukemia (ALL) were analyzed to establish the cytogenetic profile in this disease. Three questions were of particular interest. Do the chromosomal changes in T-cell ALL preferentially affect bands where genes encoding the T-cell receptor for antigen (TCR) have been mapped? Do alterations involving the TCR gene regions appear wit...
متن کاملA Bach2 link between pre-B cell receptor checkpoint and pre-B cell ALL.
Bach2 is a transcription factor required for affinity maturation of B cells. A recent study reveals, quite unexpectedly, that Bach2 also plays a key role in the pre-B cell receptor checkpoint and functions as a tumor suppressor in pre-B cell acute lymphocytic leukemia.
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ژورنال
عنوان ژورنال: Pediatric Hematology Oncology Journal
سال: 2016
ISSN: 2468-1245
DOI: 10.1016/j.phoj.2016.10.032